Do You Know... Hallucinogens

Updated May 31, 2005 5:44 PM

Types of hallucinogens: LSD, mescaline, psilocybin, PCP, cannabis, ecstasy, salvia and others

See also other brochures in the Do You Know series: LSD, Ecstasy, Cannabis and Ketamine.

What are hallucinogens?
The term hallucinogen refers to many different drugs, which are often called “psychedelic” drugs. While the effects of these drugs vary widely, all change the way people see, hear, taste, smell or feel, and affect mood and thought. At large doses, all may cause a person to hallucinate, or see, hear or feel things that aren’t really there.

Most of the hallucinogens used in North America belong to one of these six categories:

indolealkylamines, which includes LSD (d-lysergic acid diethlyamide, a semi-synthetic substance originally derived from “ergot,” a fungus that grows on rye and other grains), LSA (d-lysergic amide, from morning glory seeds), psilocybin and psilocin (from Psilocybe mushrooms) and DMT (dimethyltryptamine, from the bark of the Virola tree, and other sources)

phenylethylamines, which includes mescaline (found in peyote cactus), and “designer drugs” such as:

MDA (methylenedioxyamphetamine)
MDMA (ecstasy, methylenedioxymethamphetamine)
PMA (paramethoxyamphetamine)
2-CB (4-bromo-2,5-dimethoxyphenethylamine)
STP (2.5-domethoxy-4-methylamphetamine)
TMA (trimethoxyamphetamine).

arylcycloalkylamines, such as PCP (phencyclidine) and ketamine

cannabinoids, especially THC (tetrahydrocannabinol), found in marijuana, hash and hash oil

anticholinergics, from the plant family Solanaceae, which includes deadly nightshade (Atropa belladonna) and jimsonweed (Datura stramonium)

diterpene salvinorin-A, from the plant Salvia divinorum.
Where do hallucinogens come from?
Some hallucinogens come from mushrooms (psilocybin), cacti (mescaline) and other plants (cannabis, salvia). Of these, cannabis and psilocybin are almost always used in their natural form. Although LSD is used only in a synthesized form, a related drug, LSA, is found in nature. Other hallucinogens, such as MDMA and ketamine, are created in laboratories.

Who uses hallucinogens?
Hallucinogens have been used since ancient times, in religion, medicine, magic and prophecy. In the 1960s and 70s, hallucinogen use became a symbol of the counter-culture among young people in North America and Europe. More recently, hallucinogen use has been associated with the “rave” scene. A 2003 survey of Ontario students in grades 7 to 12 reported that, after cannabis, other hallucinogens are the most commonly used illicit drug. In the survey, 10 per cent of students reported they had used hallucinogens other than cannabis in the past year. However, use of LSD and ecstasy has decreased in recent years. Information on hallucinogen use by adults in Ontario is not available.

How do hallucinogens make you feel?
How hallucinogens make you feel depends on:

how much you use
how often and how long you use
your mood, expectation and environment
your age
whether you have certain pre-existing medical or psychiatric conditions
whether you’ve taken any alcohol or other drugs (illicit, prescription, over-the-counter or herbal).
Hallucinogens cause mostly psychoactive, or mindaltering, effects, which can be mild to intense. These effects vary from drug to drug, from person to person, from one drug-taking episode to the next, and can even change dramatically within one time of use. Effects can range from ecstasy to terror, from mild distortion of the senses to full hallucinations (where people believe that drug-induced visions or other perceptions are real).

Different types of hallucinogens produce different effects; for example: LSD produces a kaleidoscope of visual patterns and changes perception. People who take LSD usually know that the hallucinations are not real; however, the effects can appear real.
Ecstasy enhances mood and produces feelings of empathy and intimacy. It does not usually cause hallucinations.
Ketamine causes an out-of-body feeling, which may be pleasant or terrifying.
Salvia causes intense, short-lived hallucinogenic effects, different from other hallucinogens.

How long does the feeling last?
The effects of some hallucinogens, such as LSD, last for hours, while others, such as salvia, last only a short time.

Are hallucinogens dangerous?
Taking hallucinogens can be dangerous for several reasons.

Most of these drugs are illegal and unregulated, and may include toxins, or not even contain the drug they are sold as. For example, drugs sold as ecstasy are usually not pure MDMA, and have been found to contain other drugs, such as PMA, which can cause seizures and death. Drugs sold as mescaline are almost always something else.
Hallucinogens affect perception and behaviour. Taking them may cause people to become disoriented, have poor judgment and take risks.
Many hallucinogens can have very unpleasant or toxic effects (e.g., jimsonweed, deadly nightshade). Hallucinogenic plants can be mistaken for other toxic or lethal plants, for example, mushrooms.
Although research is scarce, taking hallucinogens during pregnancy may affect the development of the baby, and increase the chance of miscarriage.
Are hallucinogens addictive?
Most people who use hallucinogens do so occasionally. Repeated use of hallucinogens such as LSD or ecstasy leads to tolerance, where the drug has reduced or no effect. Sensitivity to the drug returns if the person stops using it for a period of time, and then starts again. Stopping use of hallucinogens does not usually cause symptoms of withdrawal. However, people can develop psychological dependence, in which they feel they need the drug.

What are the long-term effects of taking hallucinogens?
Hallucinogen use may, on rare occasions, result in “flashbacks,” or replays of the drug experience, days, weeks or even years after the drug was taken. Some people who take hallucinogens feel depressed or anxious long after they took the drug.

--------------------------------------------------------------------------------

©2003 Centre for Addiction and Mental Health. A PAHO/WHO Collaborating Centre.
Fully affiliated with the University of Toronto.

DISCLAIMER: Information on this site is not to be used for diagnosis, treatment or referral services and CAMH does not provide diagnostic, treatment or referral services through the Internet. Individuals should contact their personal physician, and/or their local addiction or mental health agency for further information.

ID#P13616 published April 12, 2006 11:34 AM